HSDB 3411
Aflatoxin
CAS: 1402-68-2
Molecular Formula: C17H14O6.C17H14O7.C17H12O6.C17H12O7
HSDB 3411 - Names and Identifiers
| Name | Aflatoxin |
| Synonyms | Aflatoxin HSDB 3411 Aflatoxins |
| CAS | 1402-68-2 |
| EINECS | 214-615-9 |
| InChI | InChI=1/C17H12O7/c1-20-9-6-10-12(8-3-5-22-17(8)23-10)14-11(9)7-2-4-21-15(18)13(7)16(19)24-14/h3,5-6,8,17H,2,4H2,1H3 |
HSDB 3411 - Physico-chemical Properties
| Molecular Formula | C17H14O6.C17H14O7.C17H12O6.C17H12O7 |
| Molar Mass | 1285.13 |
| Density | 1.59g/cm3 |
| Boling Point | 612.1°C at 760 mmHg |
| Flash Point | 274.2°C |
| Vapor Presure | 6.4E-15mmHg at 25°C |
| Refractive Index | 1.68 |
HSDB 3411 - Risk and Safety
| UN IDs | 3172 |
| Hazard Class | 6.1(a) |
| Packing Group | I |
HSDB 3411 - Reference Information
| (IARC) carcinogen classification | 1 (Vol. Sup 7, 56, 82, 100F) 2012 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| product description | aflatoxin is a toxic metabolite of aflatoxin and aspergillus parasiticus. it is a kind of compound containing difuran ring and coumarin (oxonaphthalene o-ketone) in its basic structure. 12 kinds have been isolated and identified. Aflatoxin is easily soluble in chloroform and methanol but insoluble in n-hexane, petroleum ether and ether. Fluorescence is generated under long-wave ultraviolet light, which is named B1,B2,G1,G2,M1,M2,P1,R1,GM and toxic alcohol according to different fluorescence colors, RF values and structures. Among them, B1 has the highest yield, the greatest toxicity and the strongest carcinogenicity. Aflatoxin is heat-resistant and can only be cracked at 280 ℃, so there is little damage at general cooking temperature. It is very stable in neutral and weak acidic solution, slightly decomposed in acidic solution with pH 1~3, and rapidly decomposed and destroyed in solution with pH 9~10. In 1961, it was discovered that peanut cakes contaminated by Aspergillus flavus can induce liver cancer in rats. In 1962, aflatoxin was identified and proved to be a strong carcinogen. Aflatoxin with double bonds at the end of difuran ring in the structure is easy to form epoxidation metabolites and enhance its toxicity, carcinogenicity and mutagenicity. Aflatoxin mainly pollutes grain and oil and its products, such as peanuts, peanut oil, corn, rice and cottonseed. Aflatoxin B1 is used as the pollution index in domestic food testing, which can be detected by thin layer chromatography and high pressure liquid phase method. |
| aflatoxin species | aflatoxin is a metabolite of Aspergillus aspergillus flavus and aspergillus parasiticus (A.parasilicus) strains, mainly aflatoxin B1, B2, G1, G2 and their metabolites M1, M2, P1, B2a, G2a, etc. They are compounds with similar structures, among them, M1 and M2 are derivatives of aflatoxin B1 and B2, and aflatoxin B1 and B2 are metabolized into M1 and M2. Aspergillus flavus mainly produced aflatoxins B1 and B2, and Aspergillus parasiticus mainly produced aflatoxins G1, G2, B1 and B2. The main contaminant of food in China is Aspergillus flavus. aflatoxin mainly pollutes grain, oil and its products such as peanuts, peanut oil, corn, rice, cotton seeds, etc. In addition, walnuts, almonds, hazelnuts, sorghum, wheat, soybeans and beans, potatoes, eggs, milk and dairy products, liver, sausages or dried fish and peppers can be contaminated by aflatoxin. From the data of my country's large-scale census of food pollution, some grains and oils and their products in high temperature and high humidity areas in southern my country are vulnerable to pollution, while North China, Northeast China, and Northwest China are generally not contaminated by aflatoxin except for individual samples. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | oral-human LDL0:0.229 mg/kg; Oral-monkey LD50:1.75 mg/kg |
| flammability hazard characteristics | combustible; combustion releases stimulating smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:04:16
